09 Feb Amenorrhea vs Dysmenorrhea
Amenorrhea vs Dysmenorrhea
Menstruation is the periodic bleeding that occurs in a girl once she attains puberty and stops when a woman attains menopause. This can occur regularly in some and irregularly in others. Some experience heavy bleeding, while others have scanty periods.
In every cycle, the uterus prepares its lining the endometrium for implanting an embryo. When this does not occur and hormone levels change, the uterus sheds the endometrium, which is what is menstruation. The average women have a 28 day cycle, but this can vary from woman to woman.
There are three main types of Period Problems: amenorrhea, menorrhagia and dysmenorrhea. These are medical terms for skipped or absent periods, abnormally heavy flow and painful cramps during menstrual cycle.
Amenorrhea: Skipped or Missed Period
A skipped or missed period is medically known as amenorrhea. It is normal during menopause and Pregnancy to have absent menstrual cycles. However, if irregular periods are happening due to unexplained causes, it can be a cause for concern. There are two types of amenorrhea: primary and secondary. Causes for amenorrhea or a skipped period can be due to hormonal, glandular or organ changes or failures. It is easier to pin point causes of secondary amenorrhea versus primary.
Primary Amenorrhea: By the age of 16, if a teenager has not started her period one should see a gynecologist.
Secondary Amenorrhea: Irregular periods, with skipped menstrual cycles for over three months. Causes could be excessive exercises, eating disorders, thyroid or pituitary gland disorders, hypothalamus dysfunction (brain area that aids reproductive hormone regulation), breast feeding, obesity, stress, polycystic ovarian syndrome, ovarian failure and fibroids, to name a few.
Menorrhagia: Heavy Flow Menstrual Cycle
Menorrhagia is excessive bleeding accompanied by clumps or clots. This leads to anemia, which in turns worsens the bleeding and hemoglobin level falls. This leads to diminished oxygen being carried to the body tissues and causes fatigue.
Causes of menorrhagia include fibroids, miscarriage, clotting disorders, cancer of the uterus or cervix, hormonal disturbances, polyps in the uterus, taking medication such as blood thinners, to name a few.
Bleeding between periods can be due to hormonal causes or due to cancers, so one should visit a gynecologist.
Dysmenorrhea: Painful Cramps During Periods
A common menstrual problem is the pain associated with heavy flow or uncomfortable cramps during a normal period, also known as dysmenorrhea. Pain in the lower abdomen, lower back radiating to the limbs is common and mainly due to the uterus contracting to shed the lining. In some cases the pain can be so severe that it could require medication. In addition to all these symptoms, you could also deal with nausea, irregular bowel movements, headaches, lightheadedness or fainting during your periods. It is also seen when a person suffers from fibroids or endometriosis.
Hence any disturbance in a period, be it irregular period, heavy flow, scanty period, painful period, bleeding lasting for more than a week, one should see a gynecologist
Primary amenorrhea is the absence of menses by age 15 in the presence of normal sexual development or when, secondary sexual characteristics are not present, the absence of menses by age 13. Secondary amenorrhea is the cessation of menses for 3 months. Because primary amenorrhea is usually a pediatric problem, this chapter will focus on secondary amenorrhea.
Note, many of the conditions that can cause secondary amenorrhea may also cause oligomenorrhea, which is defined as less than nine menstrual cycles over the course of a year, as well as menorrhagia and metrorrhagia, collectively referred to as dysfunctional uterine bleeding.
Dysmenorrhea is pain with menstruation. It is a crampy uterine pain felt in the abdomen and pelvis, which may be associated with headache, nausea, vomiting, and back or leg pain, and lasts for 24–72 hours after the start of menstrual flow. Primary dysmenorrhea occurs in the absence of any pelvic pathology. This usually starts once ovulatory cycles are established after menarche and may improve over time and after childbirth. Its prevalence is difficult to estimate but ranges from 25–50% in adult women, and up to 95% in adolescents. Secondary dysmenorrhea is the result of pelvic pathology and often starts after age 20, though it may occur earlier. It usually represents a change from usual patterns of menstrual pain and may be accompanied by menorrhagia, dyspareunia, or chronic pelvic pain.
II. Diagnostic Approach
A. What is the differential diagnosis for this problem?
The differential diagnosis for secondary amenorrhea can be classified by the anatomic location of the problem. However, most cases are caused by four broad conditions: polycystic ovarian syndrome (PCOS), hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.
Classification by anatomic location
- Intrauterine adhesions (Asherman’s syndrome)—from damage to the endometrium
- Cervical stenosis
- Premature ovarian failure—many causes in women under the age of 40 including autoimmune, genetics, chemotherapy, pelvic radiation, mumps, and idiopathic
- Tumors: granulosa-theca cell, Brenner, cystic teratoma, mucinous/serous cystadenoma, Krukenberg tumor, craniopharyngioma, metastatic disease
- Polycystic ovarian syndrome
Hypothalamus (from disruption of gonadotropin-releasing hormone)
- Excessive exercise
- Eating disorder or malnutrition
- Pseudocyesis (false pregnancy)
- Infection: tuberculosis, syphilis, encephalitis, and meningitis
- Infiltrative disease: sarcoidosis, hemochromatosis
- Chronic illness: renal or hepatic disease, diabetes, inflammatory bowel disease
- Celiac disease
- Tumors: craniopharyngioma, germinoma, hamartoma, Langerhans cell histiocytosis, teratoma, endodermal sinus tumor, lymphoma, metastatic disease
- Cranial radiation
- Pituitary tumors: prolactinomas, other hormone secreting tumors (adrenocorticotropic hormone [ACTH], thyroid stimulating hormone [TSH], growth hormone [GH], gonadotropin)
- Systemic prolactin-secreting tumors: renal cell carcinoma, ovarian dermoid cyst, teratoma, gonadoblastoma, bronchogenic carcinoma
- Metastatic disease or Langerhans cell histiocytosis
- Sheehan syndrome: pituitary necrosis after postpartum hemorrhage
- Lymphocytic hypophysitis
- Infiltrative disease: sarcoidosis, hemochromatosis
- Empty sella
- Traumatic brain injury or subarachnoid hemorrhage
- Drugs which increase prolactin secretion: oral or injectable contraceptives, classical antipsychotics, some atypical antipsychotics especially risperidone, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, H2 receptor antagonists, verapamil, opiate pain medications, cocaine
- Cushing’s syndrome
- Adult onset adrenal hyperplasia
Classification by gynecologic and non-gynecologic factors
- Secondary dysmenorrhea can be caused by gynecologic and non-gynecologic factors.
- Ovarian cysts
- Pelvic adhesions
- Pelvic inflammatory disease and other pelvic infections
- Uterine polyps
- Cervical stenosis
- Congenital obstructive Müllerian malformations
- Inflammatory bowel disease
- Irritable bowel syndrome
- Celiac disease
- Abdominal masses
- Appendicitis—areas of inflammation or adhesions from prior infection may be aggravated by pelvic congestion during menses
- Interstitial cystitis
- Urinary tract infection
- Ureteropelvic junction obstruction
B. Describe a diagnostic approach/method to the patient with this problem
Diagnosis is through history, physical examination, and tests as described in the sections below.
1. Historical information important in the diagnosis of this problem
Important basic historical information includes how long the symptoms have been present and if there are associated systemic symptoms including:
- Hot flashes, and vaginal dryness which indicate hypoestrogenism with ovarian failure
- Increase in breast size and/or galactorrhea, which suggest hyperprolactinemia
- Hirsutism, acne, or deepening of the voice to suggest hyperandrogenism as in PCOS
A complete past medical history including surgical, obstetric, and gynecologic procedures, medication list, and review of systems may provide clues to causes of amenorrhea. Social history should focus on sources of stress and, if applicable, eating and exercise habits.
The hospitalist should clarify:
- When symptoms started (i.e. near menarche or later, once cycles were more established)
- Age at menarche—dysmenorrhea is more likely with early menarche
- Duration of usual menstrual cycle, how much bleeding, and how often
- When during the cycle the pain occurs; typical is within 1–3 days of onset of menses
- If pain only occurs with menses, or if it is present at other times during the cycle (as may be the case with endometriosis)
- If pain impacts usual activities
- Response to non-steroidal anti-inflammatory medications (NSAIDs) or oral contraceptives—no response may suggest secondary cause
- Smoking history—smokers are more likely to have dysmenorrhea
2. Physical Examination maneuvers that are likely to be useful in diagnosing the cause of this problem.
Measure weight and body mass index (BMI): if elevated this may point to PCOS, and if decreased, may point to an eating disorder, malnutrition, or excessive exercise. A gynecologic examination should be done with attention to signs of atrophy from decreased estrogen, lower outflow tract obstruction, and palpable masses. Undertake a focused neurologic examination for visual fields. Other systemic exams may be useful: for example, signs of cortisol excess for Cushing’s syndrome or androgen excess in PCOS.
Examination, including gynecologic exam should be normal.
Gynecologic exam may show:
- Cervical stenosis—under normal circumstances examiner should be able to pass a probe such as a pap smear brush through the cervix
- Palpable pelvic and abdominal masses
- Signs of endometriosis—uterosacral ligament nodules with lateral displacement of cervix, visible endometriosis lesions in the vagina or cervix
If dysmenorrhea is from other systemic illness, exam should be led by historical cues.
3. Laboratory, radiographic and other tests that are likely to be useful in diagnosing the cause of this problem.
To start, check a urine or serum human chorionic gonadotropin (hCG). If this does not indicate pregnancy, the next step is to check prolactin and follicle stimulating hormone (FSH), as well as thyroid stimulating hormone (TSH). If indicated by history and examination, ultrasound can be done to look for masses or other abnormal pelvic anatomy. If adhesions are suspected, ultrasound should be followed by hysterogram or hysteroscopy. If prolactin is elevated and a pituitary tumor is on the differential diagnosis, or if FSH is in the low-to-normal range with no obvious cause (such as an eating disorder), the patient should have magnetic resonance imaging (MRI) focusing on the sella turcica to look for pituitary mass.
There are no specific tests for diagnosis other than a characteristic history and a normal examination.
The patient should have an ultrasound looking for masses or other abnormal anatomy, and a urinalysis if urologic causes are part of the differential diagnosis. Endometriosis is diagnosed by laparoscopy, though imaging may show suggestive lesions.
C. Criteria for Diagnosing Each Diagnosis in the Method Above.
- Prolactin greater than 100ng/ml: pituitary adenoma or empty sella syndrome
- Prolactin 20–100ng/ml: pregnancy, lactation, hypothyroidism, medications, renal or hepatic disease, ectopic production
- Premature ovarian failure
Normal or low FSH:
- Weight loss or excessive exercise
- Cushing’s syndrome
- Pituitary tumor, empty sella syndrome, Sheehan syndrome
- Chronic illness
Because it is a clinical diagnosis based on key historical features and a normal examination, there is no particular lab testing or imaging that should be done routinely.
For diagnosis it requires history, examination or imaging—ultrasound or MRI—suggesting pathology associated with the pain.
D. Over-utilized or “wasted” diagnostic tests associated with the evaluation of this problem.
Normal estradiol is expected with PCOS. However, levels may fluctuate and are therefore not helpful in distinguishing PCOS from other causes of amenorrhea.
The progesterone challenge test does not effectively distinguish if estrogen is present. Up to 20% of women with normal levels of estrogen and oligomenorrhea or amenorrhea have no withdrawal bleeding with progesterone. This test also has a high false negative rate.
Primary dysmenorrhea is a clinical diagnosis and there are no specific tests to confirm the diagnosis. Further testing should only be done if secondary dysmenorrhea is suspected.
III. Management while the Diagnostic Process is Proceeding
A. Management of amenorrhea and dysmenorrhea
The management of amenorrhea depends on the underlying cause. In most cases treating the underlying illness is the treatment for amenorrhea. In the case of drug-induced amenorrhea, the offending agent should be discontinued if possible. Amenorrhea from excessive exercise or weight loss can be treated by decreasing exercise or gaining weight until menses return. This is important due to the bone loss that may occur if left untreated.
Sheehan syndrome, ischemic pituitary necrosis in the setting of postpartum hemorrhage, usually presents distant in time from the inciting event. But, recognizing this existence of this diagnosis and providing prompt, appropriate supportive care in the postpartum period can prevent the condition.
NSAIDs other than aspirin are the mainstay of treatment and have been shown to reduce the pain of primary dysmenorrhea. Aspirin and acetaminophen are less effective. Topical heat has also been shown to be effective. Combined oral contraceptives may have some benefit as well, and are often used, though the evidence in support of this is less rigorous. The levonorgestrel-releasing IUD has also been shown to improve dysmenorrhea and may be equal to or better than combined oral contraceptives. There is no specific evidence for or against the use of opiate pain medications.
Treatment should be directed at the underlying cause in addition to the supportive management of pain as for primary dysmenorrhea.
B. Common Pitfalls and Side-Effects of Management of this Clinical Problem
Amenorrhea is not a common primary presenting symptom in hospital medicine, but is an important historical feature of systemic illness. Diagnosing it may depend primarily on obtaining a good history.
Prolactin and FSH levels can help to narrow the differential diagnosis of secondary amenorrhea. If the prolactin level is mildly elevated, it should be repeated as certain factors including stress, breast stimulation, and exercise may cause slight increases in prolactin.
Significant or changing dysmenorrhea in an adult woman should prompt evaluation for secondary causes.